Omics analysis of mouse brain models of human diseases.
Identifieur interne : 000021 ( Main/Exploration ); précédent : 000020; suivant : 000022Omics analysis of mouse brain models of human diseases.
Auteurs : Véronique Paban [France] ; Béatrice Loriod [France] ; Claude Villard [France] ; Luc Buee [France] ; David Blum [France] ; Susanna Pietropaolo [France] ; Yoon H. Cho [France] ; Sylvie Gory-Faure [France] ; Elodie Mansour [France] ; Ali Gharbi [France] ; Béatrice Alescio-Lautier [France]Source :
- Gene [ 1879-0038 ] ; 2017.
English descriptors
- KwdEn :
- Animals, Behavior, Animal, Brain Diseases (genetics), Brain Diseases (metabolism), Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Genomics (methods), Humans, Male, Mental Disorders (genetics), Mental Disorders (metabolism), Metabolic Networks and Pathways, Mice, Mice, Knockout, Mice, Transgenic, Neurodegenerative Diseases (genetics), Neurodegenerative Diseases (metabolism), Proteomics (methods).
- MESH :
- genetics : Brain Diseases, Mental Disorders, Neurodegenerative Diseases.
- metabolism : Brain Diseases, Mental Disorders, Neurodegenerative Diseases.
- methods : Genomics, Proteomics.
- Animals, Behavior, Animal, Disease Models, Animal, Gene Expression Profiling, Gene Regulatory Networks, Humans, Male, Metabolic Networks and Pathways, Mice, Mice, Knockout, Mice, Transgenic.
- mix :
Abstract
The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.
Url:
DOI: 10.1016/j.gene.2016.11.022
PubMed: 27871923
Affiliations:
- France
- Aquitaine, Auvergne-Rhône-Alpes, Hauts-de-France, Nord-Pas-de-Calais, Nouvelle-Aquitaine, Provence-Alpes-Côte d'Azur, Rhône-Alpes
- Bordeaux, Grenoble, Lille, Marseille
- Université de Bordeaux
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000006
- to stream PubMed, to step Curation: 000006
- to stream PubMed, to step Checkpoint: 000006
- to stream Ncbi, to step Merge: 001B63
- to stream Ncbi, to step Curation: 001B63
- to stream Ncbi, to step Checkpoint: 001B63
- to stream Hal, to step Corpus: 000830
- to stream Hal, to step Curation: 000830
- to stream Hal, to step Checkpoint: 000015
- to stream Main, to step Merge: 000021
- to stream Main, to step Curation: 000021
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Omics analysis of mouse brain models of human diseases.</title><author><name sortKey="Paban, Veronique" sort="Paban, Veronique" uniqKey="Paban V" first="Véronique" last="Paban">Véronique Paban</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address: veronique.paban@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name><affiliation wicri:level="3"><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name><affiliation wicri:level="3"><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name><affiliation wicri:level="4"><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name><affiliation wicri:level="4"><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Faure">Sylvie Gory-Faure</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:27871923</idno><idno type="pmid">27871923</idno><idno type="doi">10.1016/j.gene.2016.11.022</idno><idno type="wicri:Area/PubMed/Corpus">000006</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000006</idno><idno type="wicri:Area/PubMed/Curation">000006</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000006</idno><idno type="wicri:Area/PubMed/Checkpoint">000006</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000006</idno><idno type="wicri:Area/Ncbi/Merge">001B63</idno><idno type="wicri:Area/Ncbi/Curation">001B63</idno><idno type="wicri:Area/Ncbi/Checkpoint">001B63</idno><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-01433082</idno><idno type="url">https://hal-amu.archives-ouvertes.fr/hal-01433082</idno><idno type="wicri:Area/Hal/Corpus">000830</idno><idno type="wicri:Area/Hal/Curation">000830</idno><idno type="wicri:Area/Hal/Checkpoint">000015</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000015</idno><idno type="wicri:doubleKey">0378-1119:2016:Paban V:omics:analysis:of</idno><idno type="wicri:Area/Main/Merge">000021</idno><idno type="wicri:Area/Main/Curation">000021</idno><idno type="wicri:Area/Main/Exploration">000021</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Omics analysis of mouse brain models of human diseases.</title><author><name sortKey="Paban, Veronique" sort="Paban, Veronique" uniqKey="Paban V" first="Véronique" last="Paban">Véronique Paban</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France. Electronic address: veronique.paban@univ-amu.fr.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, INSERM UMR 1090, TAGC, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, INSERM, CRO2 UMR S911, Faculté de pharmacie, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name><affiliation wicri:level="3"><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name><affiliation wicri:level="3"><nlm:affiliation>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Univ. Lille, Inserm, CHU-Lille, UMR-S 1172, Alzheimer & Tauopathies, Lille</wicri:regionArea><placeName><region type="region">Hauts-de-France</region><region type="old region">Nord-Pas-de-Calais</region><settlement type="city">Lille</settlement></placeName></affiliation></author><author><name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name><affiliation wicri:level="4"><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name><affiliation wicri:level="4"><nlm:affiliation>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INCIA, Université de Bordeaux, Pessac, France; INCIA, UMR 5287, CNRS, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Nouvelle-Aquitaine</region><region type="old region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Faure">Sylvie Gory-Faure</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U1216, Grenoble, France; Univ. Grenoble Alpes, Grenoble Institut Neurosciences, Grenoble, France; CEA, BIG, Grenoble</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Grenoble</settlement></placeName></affiliation></author><author><name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name><affiliation wicri:level="3"><nlm:affiliation>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Aix Marseille Univ, CNRS, LNIA, FR3C, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author></analytic><series><title level="j">Gene</title><idno type="eISSN">1879-0038</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Brain Diseases (genetics)</term><term>Brain Diseases (metabolism)</term><term>Disease Models, Animal</term><term>Gene Expression Profiling</term><term>Gene Regulatory Networks</term><term>Genomics (methods)</term><term>Humans</term><term>Male</term><term>Mental Disorders (genetics)</term><term>Mental Disorders (metabolism)</term><term>Metabolic Networks and Pathways</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term><term>Neurodegenerative Diseases (genetics)</term><term>Neurodegenerative Diseases (metabolism)</term><term>Proteomics (methods)</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Brain Diseases</term><term>Mental Disorders</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain Diseases</term><term>Mental Disorders</term><term>Neurodegenerative Diseases</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genomics</term><term>Proteomics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Behavior, Animal</term><term>Disease Models, Animal</term><term>Gene Expression Profiling</term><term>Gene Regulatory Networks</term><term>Humans</term><term>Male</term><term>Metabolic Networks and Pathways</term><term>Mice</term><term>Mice, Knockout</term><term>Mice, Transgenic</term></keywords><keywords scheme="mix" xml:lang="en"><term> Amyloidosis</term><term> Autism</term><term> Huntington</term><term> Network</term><term> Parkinson</term><term> Proteomic</term><term> Schizophrenia</term><term> Tauopathy</term><term>Transcriptomic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The identification of common gene/protein profiles related to brain alterations, if they exist, may indicate the convergence of the pathogenic mechanisms driving brain disorders. Six genetically engineered mouse lines modelling neurodegenerative diseases and neuropsychiatric disorders were considered. Omics approaches, including transcriptomic and proteomic methods, were used. The gene/protein lists were used for inter-disease comparisons and further functional and network investigations. When the inter-disease comparison was performed using the gene symbol identifiers, the number of genes/proteins involved in multiple diseases decreased rapidly. Thus, no genes/proteins were shared by all 6 mouse models. Only one gene/protein (Gfap) was shared among 4 disorders, providing strong evidence that a common molecular signature does not exist among brain diseases. The inter-disease comparison of functional processes showed the involvement of a few major biological processes indicating that brain diseases of diverse aetiologies might utilize common biological pathways in the nervous system, without necessarily involving similar molecules.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Hauts-de-France</li><li>Nord-Pas-de-Calais</li><li>Nouvelle-Aquitaine</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhône-Alpes</li></region><settlement><li>Bordeaux</li><li>Grenoble</li><li>Lille</li><li>Marseille</li></settlement><orgName><li>Université de Bordeaux</li></orgName></list><tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Paban, Veronique" sort="Paban, Veronique" uniqKey="Paban V" first="Véronique" last="Paban">Véronique Paban</name></region><name sortKey="Alescio Lautier, Beatrice" sort="Alescio Lautier, Beatrice" uniqKey="Alescio Lautier B" first="Béatrice" last="Alescio-Lautier">Béatrice Alescio-Lautier</name><name sortKey="Blum, David" sort="Blum, David" uniqKey="Blum D" first="David" last="Blum">David Blum</name><name sortKey="Buee, Luc" sort="Buee, Luc" uniqKey="Buee L" first="Luc" last="Buee">Luc Buee</name><name sortKey="Cho, Yoon H" sort="Cho, Yoon H" uniqKey="Cho Y" first="Yoon H" last="Cho">Yoon H. Cho</name><name sortKey="Gharbi, Ali" sort="Gharbi, Ali" uniqKey="Gharbi A" first="Ali" last="Gharbi">Ali Gharbi</name><name sortKey="Gory Faure, Sylvie" sort="Gory Faure, Sylvie" uniqKey="Gory Faure S" first="Sylvie" last="Gory-Faure">Sylvie Gory-Faure</name><name sortKey="Loriod, Beatrice" sort="Loriod, Beatrice" uniqKey="Loriod B" first="Béatrice" last="Loriod">Béatrice Loriod</name><name sortKey="Mansour, Elodie" sort="Mansour, Elodie" uniqKey="Mansour E" first="Elodie" last="Mansour">Elodie Mansour</name><name sortKey="Pietropaolo, Susanna" sort="Pietropaolo, Susanna" uniqKey="Pietropaolo S" first="Susanna" last="Pietropaolo">Susanna Pietropaolo</name><name sortKey="Villard, Claude" sort="Villard, Claude" uniqKey="Villard C" first="Claude" last="Villard">Claude Villard</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonFranceV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000021 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000021 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonFranceV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:27871923
|texte= Omics analysis of mouse brain models of human diseases.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:27871923" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonFranceV1
| This area was generated with Dilib version V0.6.29. |  |